Format

Send to

Choose Destination
See comment in PubMed Commons below
Diabetes Technol Ther. 2011 Apr;13(4):451-6. doi: 10.1089/dia.2010.0204. Epub 2011 Feb 28.

Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects.

Author information

1
Department of Pediatrics, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Abstract

BACKGROUND:

This study compared the pharmacokinetics, postprandial glycemic response, and pain associated with intradermal lispro insulin delivery using a microneedle with that of a conventional catheter.

SUBJECTS AND METHODS:

Five subjects with type 1 diabetes were administered a bolus infusion of lispro insulin using a 9-mm-long subcutaneous catheter (control treatment) and a 0.9-mm-long microneedle (study treatment), followed by consumption of a standardized meal. Blood samples were periodically assayed for plasma glucose and free insulin levels.

RESULTS:

Intradermal insulin infusion using microneedles reached peak insulin concentrations in approximately half the time and led to greater reduction in plasma glucose levels than subcutaneous catheters. Microneedles were also significantly less painful than the catheters.

CONCLUSION:

The rapid pharmacokinetics and minimally invasive nature of intradermal insulin infusion using microneedles provide significant potential for improved diabetes management.

PMID:
21355717
PMCID:
PMC3131988
DOI:
10.1089/dia.2010.0204
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc. Icon for PubMed Central
    Loading ...
    Support Center