[STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine]

Nan Fang Yi Ke Da Xue Xue Bao. 2011 Feb;31(2):256-8.
[Article in Chinese]

Abstract

Objective: To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells.

Methods: The growth of HepG2 cells exposed to 0.125, 0.25, 0.5 and 1.0 mmol/L PE was assessed by MTT assay, and the expressions of STAT1 and STAT2 were analyzed using immunocytochemical assay.

Results: PE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group. AG490, an inhibitor of JAKs, partially reversed PE-induced growth inhibition of HepG2 cells.

Conclusion: STAT1 and STAT2 are involved in the growth inhibition of human hepatoma HepG2 cells induced by PE.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects*
  • Cell Proliferation*
  • Hep G2 Cells
  • Humans
  • Phosphatidylethanolamines / pharmacology*
  • STAT1 Transcription Factor / metabolism*
  • STAT2 Transcription Factor / metabolism*

Substances

  • Phosphatidylethanolamines
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT2 Transcription Factor
  • STAT2 protein, human
  • phosphatidylethanolamine