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J Cardiothorac Vasc Anesth. 2011 Dec;25(6):975-80. doi: 10.1053/j.jvca.2010.12.006. Epub 2011 Feb 26.

Preoperative total lymphocyte count in peripheral blood as a predictor of poor outcome in adult cardiac surgery.

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1
Department of Anaestesiology and Intensive Care, Federal State Institution Academician EN Meshalkin Novosibirsk State Research Institute of Circulation Pathology Rusmedtechnology, Novosibirsk, Russia.

Abstract

OBJECTIVE:

The aim of this study was to investigate the prognostic value of the preoperative total lymphocyte count in peripheral blood as a predictor of postoperative complications and mortality in cardiac surgery.

DESIGN:

A retrospective, observational study.

SETTING:

The Novosibirsk State Research Institute of Circulation Pathology (single institution).

PARTICIPANTS:

All adults undergoing primary cardiopulmonary bypass in 2009.

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

The cohort size was 1,368 patients operated upon with cardiopulmonary bypass. Patient characteristics, hospital mortality, postoperative complications, ventilation time, intensive care unit, and hospital stay were analyzed. A preoperative total lymphocyte count <1,500 cells/μL was associated with significantly higher mortality by univariate (p < 0.0001) and multivariate (p < 0.044) analyses. A low preoperative total lymphocyte count was associated with more frequent inotropic support (p < 0.001); postoperative heart arrhythmia (p < 0.001); dialysis-dependent acute renal failure (p < 0.001); and a prolonged ventilation time (p = 0.001), intensive care unit stay (p < 0.001), and hospital stay (p = 0.007).

CONCLUSIONS:

A low preoperative total lymphocyte count in peripheral blood is a useful prognostic criterion for the evaluation of a complicated postoperative period in cardiac patients operated under cardiopulmonary bypass.

PMID:
21354824
DOI:
10.1053/j.jvca.2010.12.006
[Indexed for MEDLINE]
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