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FEBS Lett. 2011 May 20;585(10):1495-502. doi: 10.1016/j.febslet.2011.02.025. Epub 2011 Feb 25.

Chlamydomonas reinhardtii as a new model system for studying the molecular basis of the circadian clock.

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Center for Gene Research, Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan.


The genome of the unicellular green alga Chlamydomonas reinhardtii has both plant-like and animal-like genes. It is of interest to know which types of clock genes this alga has. Recent forward and reverse genetic studies have revealed that its clock has both plant-like and algal clock components. In addition, since C. reinhardtii is a useful model organism also called "green yeast", the identification of clock genes will make C. reinhardtii a powerful model for studying the molecular basis of the eukaryotic circadian clock. In this review, we describe our forward genetic approach in C. reinhardtii and discuss some recent findings about its circadian clock.

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