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Diagn Microbiol Infect Dis. 2011 Mar;69(3):271-4. doi: 10.1016/j.diagmicrobio.2010.10.005.

Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi.

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Division of Infectious Diseases, Department of Internal Medicine, and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Republic of Korea.


We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration. This is the first case of scrub typhus in which doxycycline concentrations were measured in serum and cerebrospinal fluid. Clinicians should be alerted to the possibility that meningoencephalitis can occur because of inadequate maintenance of serum doxycycline level caused by antacids administered along with doxycycline.

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