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Trends Biochem Sci. 2011 May;36(5):262-71. doi: 10.1016/j.tibs.2011.01.006. Epub 2011 Feb 25.

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

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1
Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada. mweinfel@ualberta.ca

Abstract

The termini of DNA strand breaks induced by internal and external factors often require processing before missing nucleotides can be replaced by DNA polymerases and the strands rejoined by DNA ligases. Polynucleotide kinase/phosphatase (PNKP) serves a crucial role in the repair of DNA strand breaks by catalyzing the restoration of 5'-phosphate and 3'-hydroxyl termini. It participates in several DNA repair pathways through interactions with other DNA repair proteins, notably XRCC1 and XRCC4. Recent studies have highlighted the physiological importance of PNKP in maintaining the genomic stability of normal tissues, particularly developing neural cells, as well as enhancing the resistance of cancer cells to genotoxic therapeutic agents.

PMID:
21353781
PMCID:
PMC3134258
DOI:
10.1016/j.tibs.2011.01.006
[Indexed for MEDLINE]
Free PMC Article
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