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J Reprod Immunol. 2011 Mar;88(2):219-27. doi: 10.1016/j.jri.2011.01.006. Epub 2011 Feb 24.

Innate and acquired immunity in the human penile urethra.

Author information

1
Department of Obstetrics and Gynecology, Boston University, School of Medicine, Boston, MA 02118, USA.

Abstract

In men, the penile urethra is a primary infection site for sexually transmitted pathogens. Research on the immunology of this mucosal site has been limited in part due to sampling challenges, but available evidence indicates that the urethra contains a rich contingent of immunological mediators that can mount vigorous innate and adaptive immune responses against infectious organisms. Further research is needed to define approaches to stimulate immunity at this mucosal site to prevent the transmission of HIV-1 and other sexually transmitted pathogens.

PMID:
21353311
PMCID:
PMC3065209
DOI:
10.1016/j.jri.2011.01.006
[Indexed for MEDLINE]
Free PMC Article

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