Format

Send to

Choose Destination
Epidemics. 2009 Mar;1(1):2-13. doi: 10.1016/j.epidem.2008.07.001. Epub 2008 Nov 4.

No coexistence for free: neutral null models for multistrain pathogens.

Author information

1
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. mlipsitc@hsph.harvard.edu

Abstract

In most pathogens, multiple strains are maintained within host populations. Quantifying the mechanisms underlying strain coexistence would aid public health planning and improve understanding of disease dynamics. We argue that mathematical models of strain coexistence, when applied to indistinguishable strains, should meet criteria for both ecological neutrality and population genetic neutrality. We show that closed clonal transmission models which can be written in an "ancestor-tracing" form that meets the former criterion will also satisfy the latter. Neutral models can be a parsimonious starting point for studying mechanisms of strain coexistence; implications for past and future studies are discussed.

PMID:
21352747
PMCID:
PMC3099423
DOI:
10.1016/j.epidem.2008.07.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center