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Annu Rev Biophys. 2011;40:243-66. doi: 10.1146/annurev.biophys.093008.131331.

P-type ATPases.

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Center for Membrane Pumps in Cells and Disease--PUMPKIN, Danish National Research Foundation, University of Copenhagen, Frederiksberg C, Denmark.


P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1-P5. These subfamilies differ with respect to transported ligands and the way they are regulated.

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