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Ann Biomed Eng. 2011 Apr;39(4):1235-51. doi: 10.1007/s10439-011-0280-y. Epub 2011 Feb 25.

Intracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer.

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1
Department of Bioengineering, University of California-Los Angeles, CA 90095, USA.

Abstract

Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic molecule. However, it has been found that the therapeutic efficacy of such ligand-drug molecular conjugates can be limited, since they naturally follow the intracellular trafficking pathways of the endogenous ligands. Therefore, a thorough understanding of the intracellular trafficking properties of these ligands can lead to novel design criteria for engineering ligands to be more effective drug carriers. This review presents a few commonly used ligand/receptor systems where intracellular trafficking considerations can potentially improve the therapeutic efficacy of the ligand-drug molecular conjugates.

PMID:
21350890
PMCID:
PMC3069328
DOI:
10.1007/s10439-011-0280-y
[Indexed for MEDLINE]
Free PMC Article
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