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World J Gastroenterol. 2011 Feb 7;17(5):594-608. doi: 10.3748/wjg.v17.i5.594.

Haemostatic system in inflammatory bowel diseases: new players in gut inflammation.

Author information

1
Department of Internal Medicine and Medical Specialties, Gastroenterology Division, Catholic University of Rome, 00168 Rome, Italy.

Abstract

Inflammation and coagulation constantly influence each other and are constantly in balance. Emerging evidence supports this statement in acute inflammatory diseases, such as sepsis, but it also seems to be very important in chronic inflammatory settings, such as inflammatory bowel disease (IBD). Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events, and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels, where most severe inflammatory abnormalities occur. The aims of this review are to update and classify the type of coagulation system abnormalities in IBD, and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level. Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.

KEYWORDS:

Activated protein C; Coagulation; Crohn’s disease; Inflammation; Inflammatory bowel disease; Platelets; Ulcerative colitis

PMID:
21350708
PMCID:
PMC3040331
DOI:
10.3748/wjg.v17.i5.594
[Indexed for MEDLINE]
Free PMC Article
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