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World J Gastroenterol. 2011 Feb 7;17(5):567-71. doi: 10.3748/wjg.v17.i5.567.

Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease.

Author information

1
Institut Pasteur de Lille, Center for Infection and Immunity of Lille, F-59019 Lille, France. mathias.chamaillard@inserm.fr

Abstract

Antimicrobial peptides, including defensins, are essential effectors in host defence and in the maintenance of immune homeostasis. Clinical studies have linked the defective expression of both α- and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn's disease (CD), respectively. Only recently have the events leading to defective expression of defensins in CD been further elucidated, and are discussed herein. These events may account for CD-associated alterations in the microbiome and may subsequently precipitate the development of granulomatous inflammatory lesions in genetically-predisposed patients. We also address how these discoveries may pave the way for the development of a molecular medicine aimed at restoring gut barrier function in CD.

KEYWORDS:

Crohn’s disease; Defensins; Primary immunodeficiencies

PMID:
21350705
PMCID:
PMC3040328
DOI:
10.3748/wjg.v17.i5.567
[Indexed for MEDLINE]
Free PMC Article

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