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Nat Rev Immunol. 2011 Mar;11(3):187-200. doi: 10.1038/nri2918.

Microbial manipulation of receptor crosstalk in innate immunity.

Author information

1
University of Louisville, Department of Microbiology and Immunology, Louisville, Kentucky 40292, USA. g0haji01@louisville.edu

Abstract

In the arms race of host-microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses. In this Review, we focus on 'crosstalk manipulation' - the microbial strategies that instigate, subvert or disrupt the molecular signalling crosstalk between receptors of the innate immune system. This proactive interference undermines host defences and contributes to microbial adaptive fitness and persistent infections. Understanding how pathogens exploit host receptor crosstalk mechanisms and infiltrate the host signalling network is essential for developing interventions to redirect the host response and achieve protective immunity.

PMID:
21350579
PMCID:
PMC3077082
DOI:
10.1038/nri2918
[Indexed for MEDLINE]
Free PMC Article

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