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Bioinformatics. 2011 Apr 15;27(8):1162-3. doi: 10.1093/bioinformatics/btr102. Epub 2011 Feb 23.

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.

Author information

1
Department of Medical Informatics and Biomathematics, University of Münster, Münster and Munich Leukemia Laboratory, Munich, Germany. h.klein@uni-muenster.de

Abstract

The R453Plus1Toolbox is an R/Bioconductor package for the analysis of 454 Sequencing data. Projects generated with Roche's data analysis software can be imported into R allowing advanced and customized analyses within the R/Bioconductor environment for sequencing data. Several methods were implemented extending the current functionality of Roche's software. These extensions include methods for quality assurance and annotation of detected variants. Further, a pipeline for the detection of structural variants, e.g. balanced chromosomal translocations, is provided.

AVAILABILITY:

The R453Plus1Toolbox is implemented in R and available at http://www.bioconductor.org/. A vignette outlining typical workflows is included in the package.

CONTACT:

h.klein@uni-muenster.de

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
21349869
DOI:
10.1093/bioinformatics/btr102
[Indexed for MEDLINE]

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