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Scand J Clin Lab Invest. 2011 Apr;71(2):168-72. doi: 10.3109/00365513.2010.547947. Epub 2011 Feb 25.

The relationship between glycosylated haemoglobin (HbA1c) and measures of insulin resistance across a range of glucose tolerance.

Author information

1
Department of Pathology, King Khalid National Guard Hospital, Jeddah, Saudi Arabia. boraiaa@ngha.med.sa

Abstract

AIM:

This study aimed to assess the correlation between HbA1c and insulin resistance as measured by a variety of different indices in subjects from across the glycaemic spectrum.

METHODS:

Subjects with normal glucose tolerance (NGT; n = 24), impaired fasting glucose (IFG; n = 12), impaired glucose tolerance (IGT; n = 12), and type 2 diabetes (DM; n = 13) were studied. All had specimens taken in the context of a standard oral glucose tolerance test at their first visit and had the insulin sensitivity parameter (Si) determined by frequently-sampled intravenous glucose tolerance test at a second visit.

RESULTS:

HbA1c was more strongly associated with Si in NGT (r = - 0.65) than in IFG (r = - 0.48). Compared to other indices of insulin resistance HbA1c has minimal overlap in values (0.0%) between NGT and subjects with type 2 diabetes.

CONCLUSIONS:

HbA1c can be used as a simple and reliable marker of insulin resistance in NGT adults with relatively high insulin sensitivity.

PMID:
21348785
DOI:
10.3109/00365513.2010.547947
[Indexed for MEDLINE]

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