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Org Lett. 2011 Mar 18;13(6):1536-9. doi: 10.1021/ol200225v. Epub 2011 Feb 24.

Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis.

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1
Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, United States.

Abstract

Natural product gene clusters are often tightly regulated, resulting in gene cluster silencing in laboratory fermentation studies. The systematic overexpression of transcription factors (TFs) associated with biosynthetic gene clusters found in the genome of Burkholderia thailandensis E264 identified a set of TFs that, when overexpressed, alter the secondary metabolome of this bacterium. The isolation and characterization of burkholdacs A and B, two new acyldepsitripeptide histone deacetylase inhibitors produced by B. thailandensis overexpressing the TF bhcM, is reported.

PMID:
21348454
PMCID:
PMC3103185
DOI:
10.1021/ol200225v
[Indexed for MEDLINE]
Free PMC Article
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