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Zhonghua Nan Ke Xue. 2010 Dec;16(12):1113-6.

[Testicular dysgenesis syndrome: an update].

[Article in Chinese]

Author information

1
Department of Urology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China. alfh19@yahoo.com.cn

Abstract

Researches on the testicular dysgenesis syndrome (TDS) have flourished in the recent decade, and a widely accepted view on its pathogenesis is that environmental endocrine disrupting chemicals (EDCs) act on Leydig cells and/or testicular Sertoli cells, resulting in abnormal development of the testis and leading to the symptoms of TDS. Molecular biological studies suggest a correlation of TDS etiology with insulin-like factor 3 (INSL-3), androgen receptor (AR), P27kip, WT-1 and Müllerian inhibiting substance (MIS). This review focuses on the progress in current researches on the etiology and mechanism of TDS.

PMID:
21348205
[Indexed for MEDLINE]

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