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J Autism Dev Disord. 2011 Dec;41(12):1665-74. doi: 10.1007/s10803-011-1199-8.

The nature of covariation between autistic traits and clumsiness: a twin study in a general population sample.

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1
The Academic Centre for the Study of Behavioural Plasticity, Vita-Salute San Raffaele University, 20 via S D'Ancona, 20127, Milan, Italy.

Abstract

While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8-17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63.

PMID:
21347613
DOI:
10.1007/s10803-011-1199-8
[Indexed for MEDLINE]

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