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Eur J Med Chem. 2011 Apr;46(4):1222-31. doi: 10.1016/j.ejmech.2011.01.043. Epub 2011 Feb 4.

Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS.

Author information

1
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Abstract

In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G(1) phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect.

PMID:
21345544
DOI:
10.1016/j.ejmech.2011.01.043
[Indexed for MEDLINE]

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