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Breast Cancer Res. 2011 Jan 28;13(1):301. doi: 10.1186/bcr2802.

A local basis for progesterone action during mammary tumorigenesis - no longer RANK and file.

Author information

1
Department of Animal Science, University of California Davis, 2145 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.

Abstract

Two recent reports provide compelling insights into the role for RANK and its ligand, RANKL, in progestin-dependent mammary tumorigenesis. These findings build upon a considerable body of evidence pointing to the RANK signaling pathway as being a key mediator of progestin action in the mammary glands.

PMID:
21345282
PMCID:
PMC3109564
DOI:
10.1186/bcr2802
[Indexed for MEDLINE]
Free PMC Article
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