Send to

Choose Destination
See comment in PubMed Commons below
Korean J Urol. 2011 Jan;52(1):1-8. doi: 10.4111/kju.2011.52.1.1. Epub 2011 Jan 24.

Toward evidence-based genetic research on lifelong premature ejaculation: a critical evaluation of methodology.

Author information

  • 1Department of Psychiatry and Neurosexology, HagaHospital, The Hague, The Netherlands.


Recently, four premature ejaculation (PE) subtypes have been distinguished on the basis of the duration of the intravaginal ejaculation latency time (IELT). These four PE subtypes have different etiologies and pathogeneses. Genetic research on PE should consider the existence of these PE subtypes and the accurate measurement of the IELT with a stopwatch. Currently, three methods of genetic research on PE have been used. They differ in the investigated population, tool of measurement, study design, and variables of PE. From animal and human research, it is derived that the central serotonergic system "modulates" ejaculation, whereas the ejaculation (reflex) itself is probably not under direct influence of the serotonergic system, but rather under the influence of other neurotransmitter systems in the spinal cord. For genetic research on PE, it is important to take into account that the (serotonergic) modulation of the IELT is variable among men and may even be absent. This means that serotonergic genetic polymorphisms may only be found in men with PE who respond with an ejaculation delay treatment with a selective serotonin reuptake inhibitor.


Evidence based research; Genetics; Premature ejaculation; Serotonin

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Korean Urological Association Icon for PubMed Central
    Loading ...
    Support Center