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Pancreas. 2011 May;40(4):522-32. doi: 10.1097/MPA.0b013e31820bf8ac.

New prognostic markers for outcome of acute pancreatitis: overview of reporting in 184 studies.

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  • 11st Department of Internal Medicine & Hepato-Gastroenterology Unit, University of Ioannina School of Medicine, Ioannina, Greece.

Abstract

OBJECTIVES:

The objective of this study was to assess the reporting of studies on new prognostic markers of outcome in acute pancreatitis.

METHODS:

We used MEDLINE searches complemented with perusal of review articles' references to identify eligible English-language studies. We included studies evaluating nonroutine markers for acute pancreatitis. Eligible outcomes included Atlanta criteria, Japanese criteria for severity, multiple/single organ failure, complications, interventional treatment, hospitalization length, and death. We generated a 47-item checklist on Acute Pancreatitis Prognosis by adapting a previously constructed reporting guidance instrument for prognostic tumor markers (REMARK [Reporting Recommendations for Tumor Marker Prognostic Studies]). The checklist addresses the reporting of essential information in prognostic studies.

RESULTS:

The 184 identified eligible studies reported on 196 different prognostic markers. One hundred forty-four studies (78.3%) found at least 1 prognostic marker to be nominally statistically significant. Significant improvements over time were seen in the reporting for 17 items, but major deficiencies were noted even in 2004-2009 studies. Particularly, 12 items were reported in less than 10% of studies overall and even within the most recent studies.

CONCLUSIONS:

Despite some improvements over time, the reporting of important aspects of prognostic studies in acute pancreatitis remains suboptimal. The proposed REMARK-based checklist may help improve the quality and reporting of research in this field.

PMID:
21343832
DOI:
10.1097/MPA.0b013e31820bf8ac
[PubMed - indexed for MEDLINE]
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