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Obstet Gynecol. 2011 Mar;117(3):611-7. doi: 10.1097/AOG.0b013e31820ca504.

Breast milk hydrocodone and hydromorphone levels in mothers using hydrocodone for postpartum pain.

Author information

1
Department of Pharmacy and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego Medical Center, San Diego, California 92103-8765, USA. jsauberan@ucsd.edu

Abstract

OBJECTIVE:

To estimate the extent of passage of hydrocodone and its active metabolite, hydromorphone, into breast milk.

METHODS:

This is a pharmacokinetic study of 30 postpartum women receiving hydrocodone bitartrate for postpartum pain in the inpatient setting. Mothers donated timed breast milk samples for the analysis of hydrocodone and hydromorphone.

RESULTS:

Fully breastfed neonates received 1.6% (range 0.2%-9%) of the maternal weight-adjusted hydrocodone bitartrate dosage. When combined with hydromorphone, the total median opiate dosage from breast milk is 0.7% of a therapeutic dosage for older infants. Most mothers excreted little to no hydromorphone into breast milk.

CONCLUSION:

Standard postpartum dosages of hydrocodone bitartrate appear to be acceptable to use in women nursing newborns. Prolonged use of high dosages is not advisable.

PMID:
21343764
DOI:
10.1097/AOG.0b013e31820ca504
[Indexed for MEDLINE]

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