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Antimicrob Agents Chemother. 2011 May;55(5):2487-9. doi: 10.1128/AAC.01384-10. Epub 2011 Feb 22.

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.

Author information

1
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2, Ireland.

Abstract

The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.

PMID:
21343449
PMCID:
PMC3088215
DOI:
10.1128/AAC.01384-10
[Indexed for MEDLINE]
Free PMC Article

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