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Antimicrob Agents Chemother. 2011 May;55(5):2417-9. doi: 10.1128/AAC.01672-10. Epub 2011 Feb 22.

In vitro activity of fusidic acid (CEM-102, sodium fusidate) against Staphylococcus aureus isolates from cystic fibrosis patients and its effect on the activities of tobramycin and amikacin against Pseudomonas aeruginosa and Burkholderia cepacia.

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1
Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.

Abstract

We tested the MICs of fusidic acid (CEM-102) plus other agents against 40 methicillin-resistant Staphylococcus aureus (MRSA) isolates from cystic fibrosis patients and the activities of fusidic acid with or without tobramycin or amikacin against Pseudomonas aeruginosa, MRSA, and Burkholderia cepacia isolates from cystic fibrosis patients in a 24-h time-kill study. Fusidic acid was potent (MICs, 0.125 to 0.5 μg/ml; a single 500-mg dose of fusidic acid at 8 h averaged 8 to 12. 5 μg/ml with 91 to 97% protein binding) against all MRSA strains. No antagonism was observed; synergy occurred for one MRSA strain treated with fusidic acid plus tobramycin.

PMID:
21343445
PMCID:
PMC3088183
DOI:
10.1128/AAC.01672-10
[Indexed for MEDLINE]
Free PMC Article

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