Format

Send to

Choose Destination
See comment in PubMed Commons below
Haemophilia. 2011 Jul;17(4):571-8. doi: 10.1111/j.1365-2516.2010.02472.x. Epub 2011 Feb 22.

Pathophysiology, diagnosis and prevention of arthropathy in patients with haemophilia.

Author information

1
Children's Healthcare of Atlanta/Emory University, Atlanta, GA, USA. amy.dunn@choa.org

Abstract

Recurrent haemarthroses in patients with severe and moderate haemophilia can result in the development of one or more target joints and subsequent degenerative joint disease. This debilitating process is characterized by physical and physiological changes in articular cartilage, synovium and bone. Models of degenerative joint disease have been examined after the addition of whole blood or blood components to cell cultures or animal joints, or by monitoring biomarkers in individuals with and without haemophilia. Inhibition of cartilage-based proteoglycan synthesis and induction of proliferative synovitis are commonly observed in these models of degenerative joint disease. Clinical evaluation of joint disease includes use of specially designed physical examination and radiographic tools. Efforts to prevent or limit arthropathy include the use of prophylactic factor infusion regimens, surgical joint intervention or both.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center