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Macromol Biosci. 2011 May 12;11(5):700-9. doi: 10.1002/mabi.201000509. Epub 2011 Feb 21.

Poly(diol-co-citrate)s as novel elastomeric perivascular wraps for the reduction of neointimal hyperplasia.

Author information

1
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA.

Abstract

The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO-releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO-based therapies could be beneficial.

PMID:
21341372
PMCID:
PMC4068126
DOI:
10.1002/mabi.201000509
[Indexed for MEDLINE]
Free PMC Article

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