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Macromol Biosci. 2011 Jun 14;11(6):739-47. doi: 10.1002/mabi.201000432. Epub 2011 Feb 21.

Extracellular matrix functionalized microcavities to control hematopoietic stem and progenitor cell fate.

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Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden, Germany.


Polymeric microcavities functionalized with extracellular matrix components were used as an experimental in vitro model to investigate principles of hematopoietic stem and progenitor cell (HSPC) fate control. Using human CD133+ HSPC we could demonstrate distinct differences in HSPC cycling and differentiation dependence on the adhesion ligand specificity (i.e., heparin, collagen I) and cytokine levels. The presented microcavity platform provides a powerful in vitro approach to explore the role of exogenous cues in HSPC fate decisions and can therefore be instrumental to progress in stem cell biology and translational research toward new therapies.

[Indexed for MEDLINE]

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