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Hum Genet. 2011 May;129(5):465-72. doi: 10.1007/s00439-011-0969-x. Epub 2011 Feb 22.

Recent progress in the study of the genetics of height.

Author information

1
Montreal Heart Institute, 5000 BĂ©langer Street, Montreal, QC, Canada. guillaume.lettre@mhi-humangenetics.org

Abstract

Adult height is a classic polygenic trait of high narrow-sense heritability (h (2) = 0.8). In the late nineteenth to early twentieth century, variation in adult height was used as a model to set the foundation of the fields of statistics and quantitative genetics. More recently, with our increasing knowledge concerning the extent of genetic variation in the human genome, human geneticists have used genome-wide association studies to identify hundreds of loci robustly associated with adult height, providing new insights into human growth and development, and into the architecture of complex human traits. In this review, I highlight the progress made in the last 2 years in understanding how genetic variation controls height variation in humans, including non-Caucasian populations and children.

PMID:
21340692
DOI:
10.1007/s00439-011-0969-x
[Indexed for MEDLINE]

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