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J Clin Invest. 2011 Mar;121(3):841-4. doi: 10.1172/JCI46333. Epub 2011 Feb 21.

Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur".

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1
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. Wstrober@niaid.nih.gov

Abstract

The role of adherent-invasive E. coli (AIEC) in Crohn disease (CD) has been in debate for decades. AIEC bacteria are found in the small intestine of patients with chronic CD, but it has remained unclear whether this infection is causal or secondary to underlying immune deficiencies in CD patients. In this issue of the JCI, Chassaing and colleagues demonstrate that AIEC bacteria express an adherence factor called long polar fimbriae (LPF) that aids in the binding of these bacteria to M cells overlying Peyer's patches and subsequent entry into lymphoid tissue. These findings provide a mechanism of AIEC penetration but do not prove that AIEC is causing a primary infection in the Peyer's patches that is necessary for the initiation or persistence of CD inflammation.

PMID:
21339637
PMCID:
PMC3049399
DOI:
10.1172/JCI46333
[Indexed for MEDLINE]
Free PMC Article
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