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Arch Dermatol. 2011 Jun;147(6):719-23. doi: 10.1001/archdermatol.2011.13. Epub 2011 Feb 21.

Progression of toxic epidermal necrolysis after tanning bed exposure.

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1
Department of Dermatology, Indiana University School of Medicine, 550 N University Blvd, Indianapolis, IN 46202, USA.

Abstract

BACKGROUND:

In addition to recreational tanning bed use, UV radiation exposures are sometimes sought to self-treat skin conditions. The ability of tanning bed radiation exposure to trigger toxic epidermal necrolysis has not been reported.

OBSERVATIONS:

A young woman attempted to treat a self-limiting drug hypersensitivity reaction via tanning bed radiation exposure, which resulted in a systemic toxic epidermal necrolysis-like reaction. Studies with cultured keratinocytes and an epithelial cell line reveal that UV-A radiation can synergize with other stimuli such as phorbol esters or interleukin 1 to produce large amounts of tumor necrosis factor, providing a potential mechanism for this exaggerated reaction.

CONCLUSION:

In addition to inducing photodamage and skin cancer, tanning bed radiation exposure can trigger a toxic epidermal necrolysis-like reaction, possibly via the exaggerated production of keratinocyte cytokines such as tumor necrosis factor.

PMID:
21339416
PMCID:
PMC3119720
DOI:
10.1001/archdermatol.2011.13
[Indexed for MEDLINE]
Free PMC Article
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