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Arch Otolaryngol Head Neck Surg. 2011 Feb;137(2):175-80. doi: 10.1001/archoto.2010.244.

A higher CD105-assessed microvessel density and worse prognosis in elderly patients with laryngeal carcinoma.

Author information

1
Department of Medical and Surgical Specialties, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. gino.marioni@unipd.it

Abstract

OBJECTIVES:

To ascertain the prognostic role of endoglin (CD105)-assessed microvessel density (MVD) in patients older than 65 years with laryngeal squamous cell carcinoma (LSCC), and whether this MVD differed in the elderly patients from younger adult controls.

DESIGN:

Retrospective clinicopathologic investigation.

SETTING:

Academic tertiary referral center.

PATIENTS:

Fifty-seven consecutive elderly patients with LSCC and 19 younger adult controls.

MAIN OUTCOME MEASURE:

Image analysis of immunohistochemical reactions.

RESULTS:

In LSCCs in elderly patients, N+ stage correlated with a shorter disease-free survival (DFS) (P < .001). A higher CD105-assessed MVD was associated with disease recurrence (P = .006). The DFS was shorter in elderly patients whose CD105 expression was greater than 9.6% than in patients whose CD105 expression was 9.6% or less (P = .001). Among the elderly patients with tumors staged as N0, a higher CD105-assessed MVD correlated with disease recurrence (P = .006) and a shorter DFS (P = .001). CD105-assessed MVD in LSCC occurring in elderly patients did not differ from the situation observed in younger adult controls (P = .74).

CONCLUSIONS:

In LSCC occurring in elderly patients, CD105-assessed MVD may be a useful N-stage independent, angiogenic prognostic marker for pinpointing: (1) patients at higher risk of disease recurrence; and (2) patients with N0 tumors at higher risk of early recurrence, who may benefit from more aggressive therapy.

PMID:
21339405
DOI:
10.1001/archoto.2010.244
[Indexed for MEDLINE]

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