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J Surg Oncol. 2011 Mar 15;103(4):330-6. doi: 10.1002/jso.21697.

Selecting local therapy in the young breast cancer patient.

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  • 1Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. kingt@mskcc.org

Abstract

Survival rates among young women with breast cancer remain inferior to that of older women. Higher rates of local failure after breast conservation (BCT) have led to speculation that mastectomy may be better, yet this remains unproven. Gene expression profiling provides new insight into biological differences that may account for differences in outcomes. With careful attention to margins and appropriate use of radiation and systemic therapy, BCT remains a safe option for young women with breast cancer.

PMID:
21337567
DOI:
10.1002/jso.21697
[PubMed - indexed for MEDLINE]
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