Format

Send to

Choose Destination
See comment in PubMed Commons below
Photochem Photobiol Sci. 2011 Jun;10(6):956-63. doi: 10.1039/c0pp00336k. Epub 2011 Feb 19.

Tumour cell death induced by the bulk photovoltaic effect of LiNbO3:Fe under visible light irradiation.

Author information

1
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain. alfonso.blazquez@uam.es

Abstract

This work reports a pioneer application of the bulk photovoltaic effect in the biomedical field. Massive necrotic cell death was induced in human tumour cell cultures grown on a bulk photovoltaic material (iron-doped lithium niobate, LiNbO(3):Fe) after irradiation with visible light. Lethal doses (≈100% cell death) were obtained with low-intensity visible light sources (10-100 mW cm(-2) irradiances) and short exposure times of the order of minutes. The wavelength dependence to induce the lethal effect observed is consistent with that corresponding to the bulk photovoltaic effect generation in LiNbO(3):Fe. Necrosis also occurred when cultured tumour cells were exposed to LiNbO(3):Fe microparticles and visible light.

PMID:
21336376
DOI:
10.1039/c0pp00336k
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Support Center