Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging

Irene C M Kwan; Richard J Delley; David R W Hodgson; Gang Wu

doi:10.1039/c0cc05654e

Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging

Chem Commun (Camb). 2011 Apr 7;47(13):3882-4. doi: 10.1039/c0cc05654e. Epub 2011 Feb 18.

Authors

Irene C M Kwan¹, Richard J Delley, David R W Hodgson, Gang Wu

Affiliation

¹ Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6.

PMID: 21336356
DOI: 10.1039/c0cc05654e

Abstract

We report that the ability of disodium 5'-deoxy-5'-thioguanosine-5'-monophosphate, Na(2)(5'-GSMP), to self-associate into a helical G-quadruplex structure in aqueous solution at pH 8 is significantly higher than that of disodium guanosine-5'-monophosphate, Na(2)(5'-GMP), which supports our earlier hypothesis regarding the importance of cation bridging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cations / chemistry
G-Quadruplexes*
Guanosine / analogs & derivatives*
Guanosine Monophosphate / chemistry*

Substances

Cations
Guanosine
Guanosine Monophosphate