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Fetal Diagn Ther. 2011;30(1):35-40. doi: 10.1159/000323593. Epub 2011 Feb 19.

Prevalence and outcome of absence of ductus venosus at 11(+0) to 13(+6) weeks.

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1
Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK.

Abstract

INTRODUCTION:

To examine the prevalence and outcome of absent ductus venosus (DV) diagnosed at 11-13 weeks' gestation.

METHOD:

Prospective screening study for aneuploidies in 65,840 singleton pregnancies, including measurement of nuchal translucency (NT) thickness and examination of the DV. Prenatal findings and outcome of fetuses with absent DV were examined.

RESULTS:

Absent DV was diagnosed in 26 cases giving a prevalence of 1 in 2,532. In 15 (57.7%) cases the NT was above the 95th centile for crown-rump length. In 11 (42.3%) cases, there was an aneuploidy, mainly Turner syndrome. The incidence of aneuploidies was 66.7% (10 of 15) for those with NT above the 95th centile and 9.1% (1 of 11) in those with normal NT (p = 0.015). In addition to the aneuploidies, there were 3 cases with other abnormalities, including one case each of Ebstein anomaly, Noonan syndrome and Pierre Robin sequence. In 9 of the 11 (81.8%) fetuses with NT below the 95th centile, absent DV was an isolated finding and the pregnancies resulted in healthy live births.

CONCLUSION:

The prognosis of fetuses with absent DV depends on the measurement of NT thickness, being poor if the NT is increased and good if the NT is normal.

PMID:
21335936
DOI:
10.1159/000323593
[Indexed for MEDLINE]

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