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Cell. 2011 Feb 18;144(4):471-9. doi: 10.1016/j.cell.2011.02.002.

Epigenetic centromere propagation and the nature of CENP-a nucleosomes.

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1
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA. blackbe@mail.med.upenn.edu

Abstract

Centromeres direct chromosome inheritance, but in multicellular organisms their positions on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The major candidate for the epigenetic mark is chromatin assembled with the histone H3 variant CENP-A. Recent studies offer conflicting evidence for the structure of CENP-A-containing chromatin, including the histone composition and handedness of the DNA wrapped around the histones. We present a model for the assembly and deposition of centromeric nucleosomes that couples these processes to the cell cycle. This model reconciles divergent data for CENP-A-containing nucleosomes and provides a basis for how centromere identity is stably inherited.

PMID:
21335232
PMCID:
PMC3061232
DOI:
10.1016/j.cell.2011.02.002
[Indexed for MEDLINE]
Free PMC Article
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