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Cell. 2011 Feb 18;144(4):465-6. doi: 10.1016/j.cell.2011.01.037.

Targeting aneuploidy for cancer therapy.

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1
Cell Division and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain.

Abstract

Tumor cells frequently display an abnormal number of chromosomes, a phenomenon known as aneuploidy. Tang et al. (2011) now show that aneuploid cells are particularly sensitive to compounds that induce proteotoxic and energy stress. Could this vulnerability lead to new cancer therapies?

PMID:
21335229
DOI:
10.1016/j.cell.2011.01.037
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