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Int J Pharm. 2011 Apr 15;408(1-2):113-9. doi: 10.1016/j.ijpharm.2011.02.011. Epub 2011 Feb 16.

Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice.

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  • 1Centro de Pesquisas Aggeu Magalhães - CPqAM/FIOCRUZ, Pernambuco, Brazil. crismout


Cramoll 1,4 is a lectin extracted from seeds of Cratylia mollis Mart. Many assays have shown the cytokine release activity and pro-inflammatory profile of this lectin. Here, we used Cramoll 1,4 in the treatment of cutaneous wounds in normal and immunocompromised mice for available your cicatricial power. Surgical wounds were treated daily with a topical administration of Cramoll 1,4 and parameters as edema, hyperemia, scab, granulation and scar tissues as well as contraction of wounds were analyzed. Cramoll 1,4 wounds showed higher edema and arrival of more polimorphonuclear cells at the site of lesions. Granulation tissue and collagen fiber deposition were observed with higher intensity in all Cramoll 1,4 treated wounds and promoted excellent closing and repair of lesions in less time than other groups. Results showed that Cramoll 1,4 lectin was effective in the repair of experimental lesions in mice and can be used as a future cicatricial compound.

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