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Bioorg Med Chem Lett. 2011 Apr 1;21(7):2034-9. doi: 10.1016/j.bmcl.2011.02.019. Epub 2011 Feb 19.

Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.

Author information

1
Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. phillip.cowley@tppgd.com

Abstract

The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.

PMID:
21334892
DOI:
10.1016/j.bmcl.2011.02.019
[Indexed for MEDLINE]

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