Format

Send to

Choose Destination
Curr Biol. 2011 Feb 22;21(4):R157-9. doi: 10.1016/j.cub.2010.12.044.

Cellular reprogramming: chromatin puts on the brake.

Author information

1
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. sengupta@brandeis.edu

Abstract

Directed reprogramming of differentiated cells allows the generation of specific cell types for therapeutics and can provide unexpected insights into development. A recent study demonstrates that efficient reprogramming of Caenorhabditis elegans germ cells into neurons can be achieved by knocking down a histone chaperone gene and ectopic expression of a terminal selector transcription factor.

PMID:
21334296
DOI:
10.1016/j.cub.2010.12.044
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center