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Cytokine Growth Factor Rev. 2011 Feb;22(1):35-43. doi: 10.1016/j.cytogfr.2011.01.001. Epub 2011 Feb 18.

Regulation of hepatocyte fate by interferon-γ.

Author information

1
Department of Biological Sciences, Boise State University, 1910 University Drive, Boise, ID 83725-1515, United States.

Abstract

Interferon (IFN)-γ is a cytokine known for its immunomodulatory and anti-proliferative action. In the liver, IFN-γ can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle progression. This article reviews recent mechanistic reports that describe how IFN-γ may direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also describes a probable role for IFN-γ in modulating hepatocyte fate during liver regeneration, transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising areas of research that may lead to the development of IFN-γ as a therapy to enhance recovery from liver disease.

PMID:
21334249
PMCID:
PMC3068863
DOI:
10.1016/j.cytogfr.2011.01.001
[Indexed for MEDLINE]
Free PMC Article

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