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Bioorg Med Chem Lett. 2011 Apr 1;21(7):2030-3. doi: 10.1016/j.bmcl.2011.02.010. Epub 2011 Feb 18.

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.

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1
PanThera Biopharma, LLC, Aiea, HI 96701, USA.

Abstract

New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.

PMID:
21334206
PMCID:
PMC3059087
DOI:
10.1016/j.bmcl.2011.02.010
[Indexed for MEDLINE]
Free PMC Article
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