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J Reprod Immunol. 2011 Mar;88(2):165-9. doi: 10.1016/j.jri.2011.01.009. Epub 2011 Feb 18.

Vascular IL-10: a protective role in preeclampsia.

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1
Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.

Abstract

IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.

PMID:
21334073
PMCID:
PMC3621108
DOI:
10.1016/j.jri.2011.01.009
[Indexed for MEDLINE]
Free PMC Article
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