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Gastroenterol Clin North Am. 2011 Mar;40(1):69-85. doi: 10.1016/j.gtc.2010.12.010.

Inflammation and microflora.

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GI Motility Program, Cedars-Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA.


Irritable bowel syndrome (IBS) is the most common gastrointestinal condition, affecting 10% to 20% of adults in developed countries. Over the last few years, growing evidence has supported a new hypothesis for IBS based on alterations in intestinal bacterial composition. This article reviews the evidence for a bacterial concept in IBS and begins to formulate a hypothesis of how these bacterial systems could integrate in a new pathophysiologic mechanism in the development of IBS. Data suggesting an interaction between this gut flora and inflammation in the context of IBS is also presented.

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