1. Epilepsy Behav. 2011 Mar;20(3):545-9. doi: 10.1016/j.yebeh.2011.01.017. Epub 2011
Feb 18.

Long-term outcomes from the PEARLS randomized trial for the treatment of
depression in patients with epilepsy.

Chaytor N(1), Ciechanowski P, Miller JW, Fraser R, Russo J, Unutzer J, Gilliam F.

Author information: 
(1)Department of Neurology, University of Washington School of Medicine, Seattle,
WA, USA. chaytor@u.washington.edu

Depression is associated with higher rates of suicide and lower quality of life
in individuals with epilepsy. We previously published the 12-month outcome from
our randomized clinical trial of PEARLS (Ciechanowski P, Chaytor N, Miller J, et 
al. Epilepsy Behav. Epub 5 July 2010). The purpose of this study was to determine
the long-term effectiveness of PEARLS, a home-based collaborative care
intervention consisting of problem-solving treatment, behavioral activation, and 
psychiatric consultation, in individuals with epilepsy. Patients were randomly
assigned to PEARLS (N=40) or usual care (N=40), and assessed at baseline and 6,
12, and 18 months. Patients assigned to PEARLS achieved lower depression severity
(P<0.05) (Hopkins Symptoms Checklist-20), lower suicidal ideation (P<0.02), and
better emotional well being (QOLIE-31) (P<0.02) over 18 months, compared with
patients given the usual care. The PEARLS program significantly reduces
depressive symptoms in adults with epilepsy, and this effect is maintained for 18
months after baseline and for more than 1 year after completion of home visits.

Copyright © 2011 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.yebeh.2011.01.017 
PMID: 21333607  [Indexed for MEDLINE]