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Trends Microbiol. 2011 May;19(5):217-24. doi: 10.1016/j.tim.2011.01.004. Epub 2011 Feb 18.

Honing the message: post-transcriptional and post-translational control in attaching and effacing pathogens.

Author information

1
Microbiology and Molecular Genetics Program, Emory University, Atlanta, GA 30322, USA.

Abstract

Bacteria evolve their capacity to cause disease by acquiring virulence genes that are usually clustered in discrete genetic modules termed pathogenicity islands (PAI). Stable integration of PAIs into pre-existing transcriptional networks coordinates expression from PAIs with ancestral genes in response to diverse environmental cues. Such transcriptional controls are evident in the regulation of the locus of enterocyte effacement (LEE), a PAI of enteropathogenic and enterohemorrhagic Escherichia coli. However, recent reports indicate that global post-transcriptional and post-translational regulators, including CsrA, Hfq and ClpXP, fine-tune the transcriptional output from the LEE. In this opinion article, we highlight recent advances in the understanding of post-transcriptional and post-translational regulation in attaching and effacing pathogens.

PMID:
21333542
PMCID:
PMC3087826
DOI:
10.1016/j.tim.2011.01.004
[Indexed for MEDLINE]
Free PMC Article

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