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Int J Pediatr Otorhinolaryngol. 2011 Apr;75(4):455-60. doi: 10.1016/j.ijporl.2011.01.028. Epub 2011 Feb 17.

A meta-analysis on the effectiveness of propranolol for the treatment of infantile airway haemangiomas.

Author information

1
Department of Otolaryngology Head and Neck Surgery, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom. peridis@gmail.com

Abstract

OBJECTIVE:

To study the effectiveness of propranolol in infantile airway haemangiomas and compare the effectiveness of propranolol vs. different therapies.

METHODS:

A literature search of Ovid, Embase, the Cochrane database, Google™ Scholar, and Medline using PubMed as the search engine was performed to identify studies that analysed the effect of propranolol treatment in children with airway haemangiomas. Random-effect meta-analytical techniques were conducted for the outcome measures.

RESULTS:

Thirteen studies, comprising 36 patients were included in the analysis. Propranolol was found to be an effective intervention for the resolution of infantile airway haemangiomas (P<0.00001). Meta-analysis of effectiveness of propranolol vs. steroids, CO(2) laser, or vincristine showed that propranolol is the most effective treatment.

CONCLUSIONS:

This meta-analysis demonstrated that propranolol should be recommended as a first-line treatment in infantile airway haemangiomas. However, because of the possible side effects of propranolol, current infantile haemangioma treatment centres recommend a full cardiovascular and respiratory review be performed prior to initiation of therapy.

PMID:
21333364
DOI:
10.1016/j.ijporl.2011.01.028
[Indexed for MEDLINE]

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