Graph showing the concentrations of MXF in plasma, lung, and granuloma lesion tissues at a range of time points postdose. Plasma was sampled immediately prior to euthanasia, lesion, and lung extracts were taken from several (n = 2–5) biopsies from the lungs of each animal. From 1.5 h postdose lesion, concentrations of MXF were higher than that of normal lung. The highest concentration of MXF in granuloma was recorded at 2.17 h postdose.