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Chromosome Res. 2011 Apr;19(3):409-21. doi: 10.1007/s10577-011-9191-x.

Springs, clutches and motors: driving forward kinetochore mechanism by modelling.

Author information

1
Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, UK.

Abstract

As a mechanical system, the kinetochore can be viewed as a set of interacting springs, clutches and motors; the problem of kinetochore mechanism is now one of understanding how these functional modules assemble, disassemble and interact with one another to give rise to the emergent properties of the system. The sheer complexity of the kinetochore system points to a future requirement for data-driven mathematical modelling and statistical analysis based on quantitative empirical measurement of sister kinetochore trajectories. Here, we review existing models of chromosome motion in the context of recent advances in our understanding of kinetochore molecular biology.

PMID:
21331796
PMCID:
PMC3078324
DOI:
10.1007/s10577-011-9191-x
[Indexed for MEDLINE]
Free PMC Article
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